4.2004年诺贝尔奖获得者阿龙·切哈诺沃:《体内和体外泛素蛋白水解系统对原癌基因产物C-fos的降解:结合酶的鉴定和表征》

1. Angel, P., and M. Karin. 1991. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1072:129– 157.

2. Blumenfeld, N., H. Gonen, A. Mayer, C. E. Smith, N. R. Siegel, A. L. Schwartz, and A. Ciechanover. 1994. Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in the degradation of a non-‘‘N-end rule’’ proteins. J. Biol. Chem. 269:9574–9581.

3. Bradford, M. M. 1976. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248–254.

4. Brown, K., S. Gerstberger, L. Carlson, G. Franzoso, and U. Siebenlist. 1995. Control of IkB-a proteolysis by site-specific, signal-induced phosphorylation. Science 267:1485–1488.

5. Carillo, S., M. Pariat, A.-M. Steff, P. Roux, M. Etienne-Julan, T. Lorca, and M. Piechaczyk. 1994. Differential sensitivity of FOS and JUN family members to calpains. Oncogene 9:1679–1689.

6. Chowdary, D. R., J. J. Dermody, K. K. Jha, and H. L. Ozer. 1994. Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway. Mol. Cell. Biol. 14:1997–2003.

7. Ciechanover, A. 1994. The ubiquitin-proteasome proteolytic pathway. Cell 79:13–21.

8. Ciechanover, A., J. A. DiGiuseppe, B. Bercovich, A. Orian, J. D. Richter, A. L. Schwartz, and G. M. Brodeur. 1991. Degradation of nuclear oncoproteins by the ubiquitin system in vitro. Proc. Natl. Acad. Sci. USA 88:139–143.

9. Ciechanover, A., D. Shkedy, M. Oren, and B. Bercovich. 1994. Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2. J. Biol. Chem. 269:9582–9589.

10. Curran, T. 1988. The fos oncogene, p. 307–325. In E. P. Reddy, A. M. Skalka, and T. Curran (ed.), The oncogene book. Elsevier, Amsterdam.

11. Curran, T., and B. R. Franza, Jr. 1988. Fos and Jun: the AP-1 connection. Cell 55:395–397.

12. Curran, T., A. D. Miller, L. Zokas, and I. M. Verma. 1984. Viral and cellular Fos proteins: a comparative analysis. Cell 36:259–268.

13. Curran, T., G. Peters, C. van Bereven, N. M. Teich, and I. M. Verma. 1982. FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA. J. Virol. 44:674–682.

14. Finley, D., and V. Chau. 1991. Ubiquitination. Annu. Rev. Cell Biol. 7:25–69.

15. Flanagan, W. M., B. Corthe´sy, R. J. Bram, and G. R. Crabtree. 1991. Nuclear association of a T cell transcription factor blocked by FK-506 and cyclosporin A. Nature (London) 352:803–807.

16. Girod, P.-A., T. P. Carpenter, S. van Nocker, M. L. Sullivan, and R. D. Vierstra. 1993. Homologs of the essential ubiquitin-conjugating enzymes UBC1, 4 and 5 in yeast are encoded by a multigene family in Arabidopsis thaliana. Plant J. 3:545–552.

17. Girod, P.-A., and R. D. Vierstra. 1993. A major ubiquitin-conjugating system in wheat germ extracts involves a 15-kDa ubiquitin-conjugating enzyme (E2)homologous to the yeast UBC4/UBC5 gene products. J. Biol. Chem. 268: 955–960.

17a.Gonen, H., and A. Ciechanover. Unpublished data.

18. Gonen, H., A. L. Schwartz, and A. Ciechanover. 1991. Purification and characterization of a novel protein that is required for degradation of N-aacetylated proteins by the ubiquitin system. J. Biol. Chem. 266:19221–19231.

19. Gropper, R., R. A. Brandt, S. Elias, C. F. Bearer, A. Mayer, A. L. Schwartz, and A. Ciechanover. 1991. The ubiquitin-activating enzyme, E1, is required for stress-induced lysosomal degradation of cellular proteins. J. Biol. Chem. 266:3602–3610.

20. Haas, A. L., J. V. Warms, A. Hershko, and I. A. Rose. 1982. Ubiquitinactivating enzyme: mechanism and role in protein-ubiquitin conjugation. J. Biol. Chem. 257:2543–2548.

21. Handley-Gearhart, P. M., J. S. Trausch-Azar, A. Ciechanover, and A. L. Schwartz. 1994. Rescue of the complex temperature-sensitive phenotype of Chinese hamster ovary E36ts20 cells by expression of the human ubiquitinactivating enzyme cDNA. Biochem. J. 304:1015–1020.

22. Heller, H., and A. Hershko. 1990. A ubiquitin-protein ligase specific for type III protein substrates. J. Biol. Chem. 265:6532–6535.

23. Hershko, A., D. Ganoth, J. Pehrson, R. E. Palazzo, and L. H. Cohen. 1991. Methylated ubiquitin inhibits cyclin degradation in clam embryo extracts. J. Biol. Chem. 266:16376–16379.

24. Hershko, A., and H. Heller. 1985. Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates. Biochem. Biophys. Res. Commun. 128:1079– 1086.

25. Hershko, A., H. Heller, S. Elias, and A. Ciechanover. 1983. Components of the ubiquitin-protein ligase system: resolution, affinity purification, and role in protein breakdown. J. Biol. Chem. 258:8206–8214.

26. Hershko, A., and I. A. Rose. 1987. Ubiquitin-aldehyde: a general inhibitor of ubiquitin recycling processes. Proc. Natl. Acad. Sci. USA 84:1829–1833.

27. Hirai, S., H. Kawasaki, M. Yaniv, and K. Suzuki. 1991. Degradation of transcription factors, c-Jun and c-Fos, by calpain. FEBS Lett. 287:57–61.

28. Hochstrasser, M., M. J. Ellison, V. Chau, and A. Varshavsky. 1991. The short-lived MATa2 transcriptional regulator is ubiquitinated in vivo. Proc. Natl. Acad. Sci. USA 88:4606–4610.

29. Holt, J. C., T. Venkat Gopal, A. D. Moulton, and A. W. Nienhuis. 1986. Inducible production of c-Fos antisense RNA inhibits 3T3 cell proliferation. Proc. Natl. Acad. Sci. USA 83:4794–4798.

30. Huibregtse, J. M., M. Scheffner, and P. M. Howley. 1993. Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol. Cell. Biol. 13:775–784.

31. Jariel-Encontre, I., M. Pariat, F. Martin, S. Carillo, C. Salvat, and M. Piechaczyk. 1995. Ubiquitinylation is not an absolute requirement for degradation of c-Jun by the 26S proteasome. J. Biol. Chem. 270:11623–11627.

32. Jentsch, S. 1992. The ubiquitin conjugating system. Annu. Rev. Genet. 26:177–205.

33. Jentsch, S., J. P. McGrath, and A. Varshavsky. 1987. The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme. Nature (London) 329: 131–134.

34. Johnson, R. S., B. M. Spiegelman, and V. Papaioannou. 1992. Pleiotropic effects of a null mutation in the c-fos proto-oncogene. Cell 71:577–586.

35. Johnston,N.L.,andR.E.Cohen. 1991. Uncoupling ubiquitin-protein conjugation from ubiquitin-dependent proteolysis by the use of b,g nonhydrolyzable ATP analogues. Biochemistry 39:7514–7522.

36. Kulka, R. G., B. Raboy, R. Schuster, H. A. Parag, G. Diamond, A. Ciechanover, and M. Marcus. 1988. A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1. J. Biol. Chem. 263:15726–15731.

37. Maki, Y., T. J. Bos, C. Davis, M. Starbuck, and P. K. Vogt. 1987. Avian sarcoma virus 17 carries the jun oncogene. Proc. Natl. Acad. Sci. USA 84:2848–2852.

38. Michalek, M. T., E. P. Grant, C. Gramm, A. L. Goldberg, and K. L. Rock. 1993. A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation. Nature (London) 363:552–554.

39. Murakami, Y., S. Matsufuji, T. Kameji, S.-I. Hayashi, K. Igarashi, T. Tamura, K. Tanaka, and A. Ichihara. 1992. Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination. Nature (London) 360:597–599.

40. Murray, A. 1995. Cyclin ubiquitination: the destructive end of mitosis. Cell 81:149–152.

41. Nishizawa, M., K. Okazaki, N. Furuno, N. Watanabe, and N. Segata. 1992. The ‘‘second-codon rule’’ and autophosphorylation govern the stability and activity of Mos during meiotic cell cycle in Xenopus oocytes. EMBO J. 11:2433–2446.

42. Pagano, M., S. W. Tam, A. M. Theodoras, P. Beer-Romero, G. Del Sal, V. Chau, P. Rene´e Yew, G. F. Draetta, and M. Rolfe. 1995. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269:682–685.

43. Palombella, V. J., O. J. Rando, A. L. Goldberg, and T. Maniatis. 1994. The ubiquitin-proteasome pathway is required for processing of NF-kB1 precursor protein and the activation of NF-kB. Cell 78:773–785.

44. Papavassiliou, A. G., K. Bohmann, and D. Bohmann. 1992. Determining the effect of inducible protein phosphorylation on the DNA-binding activity of transcription factors. Anal. Biochem. 203:302–309.           

45. Papavassiliou, A. G., M. Treier, C. Chavrier, and D. Bohmann. 1992. Targeted degradation of c-Fos, but not v-Fos, by a phosphorylated signal on c-Jun. Science 258:1941–1944.

46. Reiss, Y., and A. Hershko. 1990. Affinity purification of ubiquitin-protein ligase on immobilized protein substrates. J. Biol. Chem. 265:3685–3690.

47. Riabowol, K. T., R. J. Vosatka, E. B. Ziff, N. J. Lamb, and J. R. Feramisco. 1988. Microinjection of Fos-specific antibodies blocks DNA synthesis. Mol. Cell. Biol. 8:1670–1676.

48. Rock, K. L., C. Gramm, L. Rothstein, K. Clark, R. Stein, L. Dick, D. Hwang, and A. L. Goldberg. 1994. Inhibitors of the proteasome block degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761–771.

49. Rolfe, M., P. Beer-Romero, S. Glass, J. Eckstein, I. Berdo, A. Theodoras, M. Pagano, and G. Draetta. 1995. Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6-AP). Proc. Natl. Acad. Sci. USA 92:3264–3268.

50. Scheffner, M., J. M. Huibregtse, and P. M. Howley. 1994. Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. Proc. Natl. Acad. Sci. USA 91:8797–8801.

51. Scheffner, M., J. M. Huibregtse, R. D. Vierstra, and P. M. Howley. 1993. The HPV-16 E6 and E6-AP complex function as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75:495–505.

52. Scheffner, M., U. Nuber, and J. M. Huibregtse. 1995. Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioesther cascade. Nature (London) 373:81–83.

53. Scheffner, M., B. A. Werness, J. M. Huibregtse, A. J. Levine, and P. M. Howley. 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129–1136.

54. Schuermann, M., M. Neuberg, J. B. Hunter, T. Jenuwein, R. P. Rysek, R. Bravo, and R. Mu¨ller. 1989. The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation. Cell 56:507–516.

55. Seufert, W., and S. Jentsch. 1990. Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins. EMBO J. 9:543–550.

56. Shkedy, D., H. Gonen, B. Bercovich, and A. Ciechanover. 1994. Complete reconstitution of conjugation and subsequent degradation of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system. FEBS Lett. 348:126–130.

57. Traenckner, E. B.-M., S. Wilk, and P. A. Baeuerle. 1994. A proteasome inhibitor prevents activation of NF-kB and stabilizes a newly phosphorylated form of IkB-a that is still bound to NF-kB. EMBO J. 13:5433–5441.

58. Treier, M., W. Seufert, and S. Jentsch. 1992. Drosophila Ubc1 encodes a highly conserved ubiquitin-conjugating enzyme involved in selective protein degradation. EMBO J. 11:367–372.

59. Treier,M.,L.M.Staszewski,and D.Bohmann.1994. Ubiquitin-dependent c-Jun degradation in vivo is mediated by the d domain. Cell 78:787–798.

60. van Beveren, C., F. van Straaten, T. Curran, R. Mu¨ller, and I. M. Verma. 1983. Analysis of FBJ-MuSV provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different carboxy termini. Cell 32:1241–1255.

61. Van Straaten, F., R. Mu¨ller, T. Curran, C. van Beveren, and I. M. Verma. 1983. Complete nucleotide sequence of a human c-onc gene: deduced amino acid sequence of the human c-fos gene protein. Proc. Natl. Acad. Sci. USA 80:3183–3187.

62. Wade, W. F., Z. Z. Chen, R. Maki, S. McKercher, E. Palmer, J. C. Cambier, and J. H. Freed. 1989. Altered I-A protein-mediated transmembrane signaling in B cells that express truncated I-Ak protein. Proc. Natl. Acad. Sci. USA 86:6297–6301.

63. Wang, Z.-Q., C. Ovitt, A. Grigoriadis, U. Mohle-Steinlein, U. Ruther, and E. F. Wagner. 1992. Bone and hematopoietic defects in mice lacking c-Fos. Nature (London) 360:741–745.

64. Wong, T. K., and E. Neumann. 1982. Electric field-mediated gene transfer. Biochem. Biophys. Res. Commun. 107:584–587.


分享