27.膳食核苷酸通过减轻炎症和调节大鼠肠道微生物群来预防酒精性肝损伤

1.World Health Organization, Global statusreport on alcohol and health 2014. Available from: URL:http://apps.who.int/iris/bitstream/10665/112736/1/9789240692763_eng.pdf?ua=1.

2.L. A. Streba, C. C. Vere, C. T. Strebaand M. E. Ciurea, Focus on alcoholic liver disease: From nosography totreatment,World J. Gastroenterol., 2014, 20(25), 8040–8047.

3.S. Fleming, S. Toratani, T.Shea-Donohue, Y. Kashiwabara,

S. N. Vogel and E. S. Metcalf, Pro- andAnti-Inflammatory

Gene Expression in the Murine SmallIntestine and Liver

after Chronic Exposure to Alcohol,Alcohol.: Clin. Exp. Res.,2001, 25(4), 579–589.

4.B. Lin, F. Zhang, Y. Yu, Q. Jiang, Z.Zhang, J. Wang and

Y. Li, Marine collagen peptides protectagainst early alcoholic liver injury in rats, Br. J. Nutr., 2012, 107(8),1160–1166.

5.G. Szabo, P. Mandrekar, J. Petrasek andD. Catalano, The

unfolding web of innate immunedysregulation in alcoholic

liver injury, Alcohol.: Clin. Exp. Res.,2011, 35(5), 782–786.

6.A. Rocco, D. Compare, D. Angrisani, M.Sanduzzi

Zamparelli and G. Nardone, Alcoholicdisease: Liver and

beyond, World J. Gastroenterol., 2014,20(40), 14652–14659.

7.P. D. Cani and N. M. Delzenne, Gutmicroflora as a target

for energy and metabolic homeostasis,Curr. Opin. Clin.

Nutr. Metab. Care., 2007, 10(6), 729–734.

8.S. R. Gill, M. Pop, R. T. Deboy, P. B.Eckburg,

P. J. Turnbaugh, B. S. Samuel, J. I.Gordon, D. A. Relman,

C. M. Fraser-Liggett and K. E. Nelson,Metagenomic analy

sis of the human distal gut microbiome,Science, 2006,

312(5778), 1355–1359.

9.P. J. Turnbaugh, R. E. Ley, M. Hamady,C. M. Fraser

Liggett, R. Knight and J. I. Gordon, Thehuman micro

biome project, Nature, 2007, 449(7164),804–810.

10.F. Casafont Morencos, G. de las HerasCastaño, L. Martín

Ramos, M. J. Arias, F. Ledesma and F. PonsRomero, Small

bowel bacterial overgrowth in patientswith alcoholic

cirrhosis, Dig. Dis. Sci., 1996, 41(3),552–556.

11.A. Keshavarzian, A. Farhadi, C. B.Forsyth, J. Rangan,

S. Jakate, M. Shaikh, A. Banan and J. Z.Fields, Evidence

that chronic alcohol exposure promotesintestinal oxidative stress,intestinal hyperpermeability and endotoxemia priorto development of alcoholic steatohepatitis in rats, J. Hepatol., 2009, 50(3),538–547.

12.H. J. Wang, B. Gao, S. Zakhari and L.E. Nagy, Inflam

mation in Alcoholic Liver Disease, Annu.Rev. Nutr., 2012,

32, 343–368.

13.A. W. Yan, D. E. Fouts, J. Brandl, P.Stärkel, M. Torralba, E. Schott, H. Tsukamoto, K. E. Nelson, D. A. Brenner andB. Schnabl, Enteric dysbiosis associated with a mouse model of alcoholic liverdisease, Hepatology, 2011, 53(1), 96–105.

14.P. Mandrekar and G. Szabo, Signallingpathways in alcoholinduced liver inflammation, J. Hepatol., 2009, 50(6),1258–1266.

15.A. Parlesak, C. Schäfer, T. Schütz, J.C. Bode and C. Bode, Increased intestinal permeability to macromolecules andendotoxemia in patients with chronic alcohol abuse in

difffferent stages of alcohol-inducedliver disease, J. Hepatol., 2000, 32(5), 742–747.

16.M. Fujimoto, M. Uemura, Y. Nakatani, S.Tsujita,

K. Hoppo, T. Tamagawa, H. Kitano, M.Kikukawa, T. Ann,

Y. Ishii, H. Kojima, S. Sakurai, R.Tanaka, T. Namisaki,

R. Noguchi, T. Higashino, E. Kikuchi, K.Nishimura,

A. Takaya and H. Fukui, Plasma endotoxinand serum cyto

kine levels in patients with alcoholichepatitis: relation to severity of Liver disturbance, Alcohol.: Clin. Exp.Res., 2000,24(4 Suppl), 48S–54S.

17.A. A. Nanji, K. Jokelainen, A.Rahemtulla, L. Miao, F. Fogt,H. Matsumoto, S. R. Tahan and G. L. Su, Activationof

nuclear factor kappa B and cytokineimbalance in experi

mental alcoholic liver disease in the rat,Hepatology, 1999, 30(4), 934–943.

18.M. G. Neuman, Y. Maor, R. M. Nanau, E.Melzer, H. Mell,

M. Opris, L. Cohen and S. Malnick,Alcoholic Liver Disease:

Role of Cytokines, Biomolecules, 2015,5(3), 2023–2034.

19 M. M. Jaurigue and M. S. Cappell,Therapy for alcoholic

liver disease, World J. Gastroenterol.,2014, 20(9), 2143–2158.

20.M. I. Torres, M. I. Fernández, A. Giland A. Ríos, Dietary nucleotides have cytoprotective properties in rat liverdamaged by thioacetamide, Life Sci., 1998, 62(1), 13–22.

21.S. Iijima, T. Tsujinaka, M. Kishibuchi,Y. Kido, C. Ebisui, K. Kan, M. Yano and T. Mori, A total parenteral nutrition

solution supplemented with a nucleosideand nucleotide

mixture sustains intestinal integrity, butdoes not stimulate intestinal function after massive bowel resection inrats,Nutr, 1996, 126(3), 589–595.

22 M. E. Evans, J. Tian, L. H. Gu, D. P.Jones and T. R. Ziegler, Dietary Supplementation With Orotate and UracilIncreases Adaptive Growth of Jejunal Mucosa After Massive Small Bowel Resectionin Rats, JPEN, J. Parenter. Enteral Nutr., 2005, 29(5), 315–321.

23.A. Gil, Modulation of the immuneresponse mediated by

dietary nucleotides, Eur. J. Clin. Nutr.,2002, 56(Suppl. 3),

S1–S4.

24.A. Singhal, G. Macfarlane, S.Macfarlane, J. Lanigan,

K. Kennedy, A. Elias-Jones, T. Stephenson,P. Dudek and

A. Lucas, Dietary nucleotides and fecalmicrobiota in

formula-fed infants: a randomizedcontrolled trial,

Am. J. Clin. Nutr., 2008, 87(6),1785–1792.

25.C. Quast, E. Pruesse, P. Yilmaz, J.Gerken, T. Schweer,

P. Yarza, J. Peplies and F. O. Glöckner,The SILVA ribosomal

RNA gene database project: improved dataprocessing and

web-based tools, Nucleic Acids Res., 2013,41(Database

issue), D590–D596.

26.Q. Wang, G. M. Garrity, J. M. Tiedjeand J. R. Cole, Naive

Bayesian classifier for rapid assignmentof rRNA sequences

into the new bacterial taxonomy, Appl.Environ. Microbiol.,

2007, 73(16), 5261–5267.

27.M. A. Ortega, M. C. Nunez, A. Gil andA. Sánchez-Pozo,

Dietary nucleotides accelerate intestinalrecovery after food

deprivation in old rats, J. Nutr., 1995,125(6), 1413–1418.

28.C. P. Dancey, E. A. Attree and K. F.Brown, Nucleotide supplementation: a randomised double-blind placebo controlledtrial of IntestAidIB in people with Irritable Bowel Syndrome [ISRCTN67764449],Nutr. J., 2006, 5, 16.

29.Y. Wang, I. Kirpich, Y. Liu, Z. Ma, S.Barve, C. J. McClain and W. Feng, Lactobacillus rhamnosus GG treatment

potentiates intestinal hypoxia-induciblefactor, promotes

intestinal integrity and amelioratesalcohol-induced liver injury, Am. J. Pathol., 2011, 179(6), 2866–2875.

30.B. Koletzko, S. Baker, G. Cleghorn, U.F. Neto, S. Gopalan,O. Hernell, Q. S. Hock, P. Jirapinyo, B. Lonnerdal,

P. Pencharz, H. Pzyrembel, J.Ramirez-Mayans, R. Shamir,

D. Turck, Y. Yamashiro and D. Zong-Yi,Global standard

for the composition of infant formula:recommendations

of an ESPGHAN coordinated internationalexpert group,

J. Pediatr. Gastroenterol. Nutr., 2005,41(5), 584–599.

31.M. Xu, Y. Ma, L. Xu, Y. Xu and Y. Li,Developmental effffects of dietary nucleotides in second-generation weanedrats, J. Med. Food, 2013, 16(12), 1146–1152.

32.B. Gao and R. Bataller, Alcoholic liverdisease: pathogenesis and new therapeutic targets, Gastroenterology, 2011,141(5), 1572–1585.

33.J. Liu, Ethanol and liver: recentinsights into the mechanisms of ethanol-induced fatty liver, World J.Gastroenterol., 2014, 20(40), 14672–14685.

34.N. Horiguchi, L. Wang, P. Mukhopadhyay,O. Park, W. I. Jeong, F. Lafdil, D. Osei-Hyiaman, A. Moh, X. Y. Fu,

P. Pacher, G. Kunos and B. Gao, Cell type-dependentpro

and anti-inflammatory role of signaltransducer and activator of transcription 3 in alcoholic liver injury,Gastroenterology, 2008, 134(4), 1148–1158.

35.F. Hong, W. H. Kim, Z. Tian, B. Jaruga,E. Ishac, X. Shen

and B. Gao, Elevated interleukin-6 duringethanol con

sumption acts as a potential endogenousprotective cyto

kine against ethanol-induced apoptosis inthe liver:

involvement of induction of Bcl-2 andBcl-x(L) proteins,

Oncogene, 2002, 21(1), 32–43.

36.L. Bavia, Í. A. de Castro and L. Isaac,C57BL/6 and A/J Mice Have Difffferent Inflammatory Response and Liver LipidProfile in Experimental Alcoholic Liver Disease, Mediators Inflammation, 2015,2015, 491641.

37.F. M. Chang, S. M. Reyna, J. C.Granados, S. J. Wei,

W. Innis-Whitehouse, S. K. Maffiffiffi, E.Rodriguez, T. J. Slaga and J. D. Short, Inhibition of neddylation represseslipopolysaccharide-induced proinflammatory cytokine production in macrophagecells, J. Biol. Chem., 2012, 287(42), 35756– 35767.

38.V. Purohit, J. C. Bode, C. Bode, D. A.Brenner,

M. A. Choudhry, F. Hamilton, Y. J. Kang,A. Keshavarzian,

R. Rao, R. B. Sartor, C. Swanson and J. R.Turner, Alcohol,

intestinal bacterial growth, intestinalpermeability to

endotoxin, and medical consequences:summary of a

symposium, Alcohol, 2008, 42(5), 349–361.

39.D. Compare, P. Coccoli, A. Rocco and O.M. Nardone,

Maria .S. De, M. Cartenì, G. Nardone,Gut–liver axis: the

impact of gut microbiota on non alcoholicfatty liver

disease, Nutr., Metab. Cardiovasc. Dis,2012, 22(6), 471–476.

40.I. A. Kirpich, N. V. Solovieva, S. N.Leikhter, N. A. Shidakova, O.V.Lebedeva,P. I. Sidorov, T. A. Bazhukova, A. G.Soloviev,S. S. Barve, C. J. McClain and M. Cave, Probiotics restore bowel floraand improve liver enzymes in human alcoholinduced liver injury: a pilot study,Alcohol, 2008, 42(8), 675–682.

41.S. Leclercq, S. Matamoros, P. D. Cani,A. M. Neyrinck,

F. Jamar, P. Stärkel, K. Windey, V.Tremaroli, F. Bäckhed,

K. Verbeke, P. de Timary and N. M.Delzenne, Intestinal

permeability, gut-bacterial dysbiosis, andbehavioral

markers of alcohol-dependence severity,Proc. Natl. Acad.

Sci. U. S. A., 2014, 111(42), E4485–E4493.

42.A. W. Yan, D. E. Fouts, J. Brandl, P.Stärkel, M. Torralba,E. Schott, H. Tsukamoto, K. E. Nelson, D. A. Brenner andB. Schnabl, Enteric dysbiosis associated with a mouse model of alcoholic liverdisease, Hepatology, 2011, 53(1),96–105.

43.S. Ceccarelli, V. Nobili and A. Alisi,Toll-like receptor mediated signaling cascade as a regulator of the inflammationnetwork during alcoholic liver disease, World J. Gastroenterol., 2014, 20(44),16443–16451.

44.C. Schäfer, A. Parlesak, C. Schütt, J.C. Bode and C. Bode,Concentrations of lipopolysaccharide- bindingprotein,bactericidal/permeability-increasing protein, soluble CD14 and plasmalipids in relation to endotoxaemia in patients with alcoholic liver disease,Alcohol, 2002, 37(1), 81–86.

45.I. Hritz, P. Mandrekar, A. Velayudham,D. Catalano,

A. Dolganiuc, K. Kodys, E. Kurt-Jones andG. Szabo, The

critical role of toll-like receptor (TLR)4 in alcoholic liver disease is independent of the common TLR adapter

MyD88, Hepatology, 2008, 48(4), 1224–1231.

46.C. A. Bradham, J. Plümpe, M. P. Manns,D. A. Brenner and

C.Trautwein, Mechanisms of hepatictoxicity. I. TNF

induced liver injury, Am. J. Physiol.,1998, 275(3 Pt 1),

G387–G392.

47.C. J. Lin, C. C. Chiu, Y. C. Chen, M.L. Chen, T. C. Hsu and B. S. Tzang, Taurine Attenuates Hepatic Inflammation

in Chronic Alcohol-Fed Rats ThroughInhibition of

TLR4/MyD88 Signaling, J. Med. Food, 2015,18(12), 1291–

1298.

48.J. Khoury, J. C. Ibla, A. S. Neish andS. P. Colgan, Antiinflammatory adaptation to hypoxia through adenosinemediatedcullin-1 deneddylation, J. Clin. Invest., 2007, 117(3), 703–711. Paper Food& Function

2908 | Food Funct., 2016, 7, 2898–2908 This journal is © The Royal Society of Chemistry 2016 ViewArticle Online

Published on 24 May 2016. Downloaded byFLORIDA ATLANTIC UNIVERSITY


分享