1.WHO.Global status report on alcohol andhealth-2014[EB/OL].[2016-03-01].http://www.who.int/substance_abuse/publications/global_alcohol_report/msb_gsr_2014_1.pdf?ua=1.

2.Yuan Q,Hong S,Han S,et al.Preconditioningwith physiological levels of ethanol protect kidney againstischemia/reperfusion injury by modulating oxidative stress[J].PLoSOne,2011,6(10): e25811.

3.Holen E, Bjorge O A,Jonsson R.Dietarynucleotides and human immune cells.II.Modulation of PBMC growth and cytokinesecretion[J].Nutrition, 2006, 22(1): 90-96.

4.Xu M, Ma Y, Xu L, et al. Developmentaleffects of dietary nucleotides in second-generation weaned rats[J].Journal ofMedicinal Food,2013,16(12): 1146-1152.

5.Koletzko B, Baker S, Cleghorn G, et al.Global standard for the composition of infant formula: recommendations of anESPGHAN coordinated international expert group[J]. Journal of PediatricGastroenterology and Nutrition, 2005, 41(5): 584-599.

6.马奕, 徐琳琳, 许雅君, 等. 外源核苷酸对多代大鼠血清尿酸水平及肾脏损伤的影响[J].中国生育健康杂志,2009,20(4): 219-222.Ma Yi,XuLing,Xu Yajun,et al.The effect of exogenous nucleotides on serum uric levelsand renal function in mult- generation rats[J].Chinese Journal of ReproductiveHealth,2009,20(4): 219- 222.

7.Vamvakas S, Teschner M, Bahner U, et al.Alcohol abuse: potential role in electrolyte disturbances and kidneydiseases[J].Clinical Nephrology,1998,49(4): 205-213.

8.曹艳雪,王炳元,傅宝玉.酒精性肝肾损害及肾层粘蛋白、Ⅲ型胶原的表达[J].世界华人消化杂志,2001,9(10):1134-1138.

Cao Xueyan, Wang Bingyuan, Fu Baoyu.Alcoholic hepatic and renal lesion and expression of laminin, collagen Ⅲ in kidney[J].WorldChinese Journal of Digestology, 2001, 9(10): 1134-1138.

9.Cai X, Bao L, Wang N, et al. Dietarynucleotides protect against alcoholic liver injury by attenuating inflammationand regulating gut microbiota in rats[J].Food Function, 2016, 7(6): 2898-2908.

10.Williams M D, Nadler J L. Inflammatorymechanisms of diabetic complications[J]. Current Diabetes Reports, 2007, 7(3):242-248.

11.张丽娜, 谢席胜, 左川, 等.人参皂甙Rg1对糖尿病肾病大鼠 TNF-α、MCP-1表达的影响[J].四川大学学报(医学版),2009, 40(3): 466-471.Zhang Lina, Xie Xisheng, Zuo Chuan, et al. Effect ofginsenoside Rgl on the expression of TNF-α and MCP-1 in rats with diabeticnephropathy[J]. Journal of Sichuan University (Medical Science Edition), 2009,40(3): 466-471.

12.张苏皖, 李素梅, 翟斐, 等. 螺内酯对DM2大鼠肾脏保护及ICAM-1 表达的影响[J].放射免疫学杂志,2011, 24(6): 616-619. ZhangSuwan, Li Sumei, Zhai Fei, et al. Effect of spironolactone on renal andintercellular adhesion molecule- 1 expression in type 2 diabetic rats[J].Journal of Radioimmunology, 2011, 24(6): 616-619.

13.朱彩凤, 朱斌, 魏升, 等. 雷公藤甲素对TNF-α 诱导的肾系膜细胞MCP-1和ICAM-1表达干预及其机制的研究[J]. 中国中西医结合肾病杂志, 2011, 12(6): 488-492.Zhu Caifeng, Zhu Bin, Wei Sheng, et al.Effects of triptolide on TNF-

α induced mesangial MCP-1, ICAM-1expression and its mechanism [J]. Chinese Journal of Integrated Traditional andWestern Nephrology, 2011, 12(6): 488-492.

14.王东, 王亿平, 刘玲, 等. 血浆P-选择素及细胞间黏附分子-1在慢性肾脏病患者中表达的临床意义[J].辽宁中医药大学学报, 2010, 12(7): 82-84.Wang Dong,Wang Yiping, Liu Ling, et al. Clinical significance of blood plasm P- selectionand intercelluar adhesion molecule- 1 in patients with chronic kidneydisease[J]. Journal of Liaoning University

of Traditional Chinese Medicine, 2010,12(7): 82-84.

15.Wada T, Furuichi K, Sakai N, et al.Gene therapy via blockade of monocyte chemoattractant protein- 1 for renalfibrosis[J].Journal of the American Society of Nephrology, 2004, 15(4):940-948.

16.郑海兰, 陈瑛. 贝那普利在大鼠酒精性肾损伤中作用的探讨[J]. 中国现代医学杂志, 2009, 19(13): 1934-1937.

Zheng Hailan, Chen Ying. The role ofbenazepril in alcohol induce rat renal injury[J]. China Journal of ModernMedicine, 2009, 19(13):1934-1937.

17.陶小红, 吕晓云, 邱皓, 等. 中药利湿活血方对酒精性肾损害大鼠尿单核细胞趋化蛋白-1及β_2-微球蛋白的影响[J].中医研究, 2011, 24(2): 14-16.Tao Xiaohong, Lü Xiaoyun, Qiu Hao, et al.Effects of HLP on MCP-1 and β2- MG in urine of alcoholic renal injury rats[J].Traditional Chinese Medicine Research, 2011, 24(2): 14-16.

18.Schetinger M R, Morsch V M, Bonan C D,et al. NTPDase and 5'-nucleotidase activities in physiological and diseaseconditions: new perspectives for human health[J]. Biofactors, 2007, 31(2):77-98.

19.李石营, 施用晖, 乐国伟. 日粮核苷酸对机体炎症抗炎症平衡体系的影响[J].中国兽医科学,2006,36(1): 66-69.Li Shiying, ShiYonghui, Le Guowei. Effects of dietary nucleotides on inflammatory andanti-inflammatory balance[J]. Veterinary Science in China, 2006, 36(1): 66-69.

20.Korb V,Tep K,Escriou V,et al.Currentdata on ATP-containing liposomes and potential prospects to enhance cellularenergy status for hepatic applications[J]. Crit Rev Ther Drug Carrier Syst,2008, 25(4): 305-345.

21.Tryggvason K, Wartiovaara J. How doesthe kidney filter plasma?[J].Physiology (Bethesda), 2005, 20(4): 96-101.

[22] Lemley K V. Glomerular pathology andthe progression of chronic kidney disease[J].American Journal of Physiology-Renal Physiology, 2016, 310(11): F1385-F1388.

23.朱颖. 肾小球足细胞分子表达与氧化应激反应的关系[D]. 合肥: 安徽医科大学,2009.ZuYing. Relationship between expression of glomerular slit diaphragm molecule andoxidative stress reaction[D].Hefei: Anhui Medical University, 2009.

24.Fukuda A, Wickman L T, Venkatareddy MP, et al. Urine podocin:Nephrin mRNA ratio (PNR) as a podocyte stressbiomarker[J]. Nephrology Dialysis Transplantation, 2012, 27(11): 4079-4087.

25.郭永月, 徐杰, 邢佳, 等. 黑牛肝菌多糖对小鼠酒精性肝损伤的改善作用[J]. 食品工业科技, 2015(24): 325-328.Guo Yongyue,Xu Jie, Xing Jia, et al. Protective effect of

polysaccharides from Boletus aereus onalcoholic kidney injury of mice [J].Science and Technology of Food Industry,2015(24): 325-328.

26.牛霞, 鹿玲, 陈珂, 等. 肾小球足细胞裂隙膜蛋白Podocin 的变化与氧化应激反应[J]. 安徽医科大学学报, 2007, 42(3): 286-289.Niu Xia, Lu Ling, Chen Ke, et al. Podocin inglomerular podocyte slit diaphragm and oxidative stress[J]. Acta UniversitatisMedicinalis Anhui, 2007, 42(3): 286-289.

27.Hong F, Wu N, Ge Y, et al. Nanosizedtitanium dioxide resulted in

the activation of TGF-beta/Smads/p38MAPKpathway in renal inflammation and fibration of mice[J]. Journal of BiomedicalMaterials Research Part A, 2016, 104(6): 1452-1461.

28.Das S K, Mukherjee S, Vasudevan D M.Effects of long term ethanol consumption mediated oxidative stress on neovesselgeneration in liver [J]. Toxicology mechanisms and methods, 2012, 22(5):375-382.

29.Tirapelli L F, Martins-Oliveira A,Batalhao M E, et al. Ethanol consumption increases the expression ofendothelial nitric oxide synthase, inducible nitric oxide synthase andmetalloproteinases in the rat kidney[J]. Journal of Pharmacy and Pharmacology,2012, 64(1): 68-76.